Charles Dexter Wards wife enlists the help of a private detective to find out what her husband is up to in a remote cabin owned by his family for centuries. Thehusband is a chemical engineer| and the smells from his experiments (and the delivery of what appear to be human remains at all hours) are beginning to arouse theattention of neighbors and local law enforcement officials. When the detective and wife find a diary of the husbands ancestor from 1771| and reports of gruesomemurders in the area begin to surface| they begin to suspect that some very unnatural experiments are being conducted in the old house. Based on an H.P. Lovecraft肯尼迪总统的遇刺让身为他贴身保镳的弗兰克（克林特·伊斯特伍德 Clint Eastwood 饰）堕入了自责的情感中不克不及自拔。即便多年曩昔，但只要一想到此时，弗兰克总感觉是本身的掉职和年夜意造成了这一悲剧。某一日，一个神秘的德律风引发了他的警悟。打德律风的汉子名叫米奇（约翰·马尔科维奇 John Malkovich 饰），他告知弗兰克，本身筹办暗算现任总统，并约请弗兰克玩一个所谓的“游戏”，这个游戏的成败将直接影响总统的命运。 旧事重演，这一次，弗兰克决议不管若何都要庇护总统的平安。这个米奇究竟是谁？他这么做的目标安在？在连续串的疑问眼前，一场剧烈而又危险的追杀游戏逐步睁开。